Providing Targeted Cancer Diagnostics



Wong NACS, Beavers S, Gill P, Heryet A, Linares J. Calponin and MUC6 complement inhibin as diagnostic immunomarkers of serous cystadenoma in endoscopic ultrasound guided aspiration/biopsy specimens. Histopathology. 2021 Aug 79;2:252-259. PMID: 33657658.


Dodson A, Parry S, Lissenberg‐Witte B, Haragan A, Allen D, O'Grady A, McClean E, Hughes J, Miller K, Thunnissen E. External quality assessment demonstrates that PD‐L1 22C3 and SP263 assays are systematically different. J Pathol Clin Res. 2020 Apr 6;2:138-145. PMID: 31849189

Gaifulina R , Caruana DJ , Oukrif D , Guppy NJ , Culley S , Brown R , Bell I, Rodriguez-Justo M , Lau K , Thomas GMH . Rapid and complete paraffin removal from human tissue sections delivers enhanced Raman spectroscopic and histopathological analysis. Analyst. 2020 Feb 17;145(4):1499-1510. PMID: 31894759.


Maurice JB, Garvey L, Tsochatzis EA, Wiltshire M, Cooke G, Guppy N, McDonald J, Marchesi J, Nelson M, Kelleher P, Goldin R, Thursz M, Lemoine M. Monocyte-macrophage activation is associated with nonalcoholic fatty liver disease and liver fibrosis in HIV monoinfection independently of the gut microbiome and bacterial translocation. AIDS. 2019 Apr 1;33(5):805-814. PMID: 30882489.

Kumar N, Alrifai D, Kolluri KK, Sage EK, Ishii Y, Guppy N, Borg E, Falzon M, Nankivell M, Nicholson AG, Janes SM. Retrospective response analysis of BAP1 expression to predict the clinical activity of systemic cytotoxic chemotherapy in mesothelioma. Lung Cancer. 2019 Jan;127:164-166. PMID: 30642545.


Brilha S, Chong DLW, Khawaja AA, Ong CWM, Guppy NJ, Porter JC, Friedland JS. Integrin a2b1 Expression Regulates Matrix Metalloproteinase-1-Dependent Bronchial Epithelial Repair in Pulmonary Tuberculosis. Front Immunol. 2018 Jun 22;9:1348.

Lewis AT, Gaifulina R, Guppy NJ, Isabelle M, Dorney J, Lloyd GR, Rodriguez-Justo M, Kendall C, Stone N, Thomas GM. Developing Raman spectroscopy as a diagnostic tool for label-free antigen detection. J Biophotonics. 2018 Feb;11(2).

Kolluri KK, Alifrangis C, Kumar N, Ishii Y, Price S, Michaut M, Williams S, Barthorpe S, Lightfoot H, Busacca S, Sharkey A, Yuan Z, Sage EK, Vallath S, Le Quesne J, Tice DA, Alrifai D, von Karstedt S, Montinaro A, Guppy N, Waller DA, Nakas A, Good R, Holmes A, Walczak H, Fennell DA, Garnett M, Iorio F, Wessels L, McDermott U, Janes SM. Loss of functional BAP1 augments sensitivity to TRAIL in cancer cells. Elife. 2018 Jan 18;7.


Beeken RJ, Croker H, Heinrich M, Obichere A, Finer N, Murphy N, Goldin R, Guppy NJ, Wilson R, Fisher A, Steptoe A, Gunter MJ, Wardle J. The Impact of Diet-Induced Weight Loss on Biomarkers for Colorectal Cancer: An Exploratory Study (INTERCEPT). Obesity. 2017 Nov;25 Suppl 2:S95-S101.

Byng-Maddick R, Turner CT, Pollara G, Ellis M, Guppy NJ, Bell LCK, Ehrenstein MR, Noursadeghi M. Tumor Necrosis Factor (TNF) Bioactivity at the Site of an Acute Cell-Mediated Immune Response Is Preserved in Rheumatoid Arthritis Patients Responding to Anti-TNF Therapy. Front Immunol. 2017 Aug 4;8:932.

Lee AM, Guppy N, Bainbridge J, Jahns H. Multiple myeloma in an Amur tiger (Panthera tigris altaica). Open Vet J. 2017;7(4):300-305.

Chan AS, Mudhar H, Shen SY, Lang SS, Fernando M, Hilmy MH, Guppy NJ, Rennie I, Dunkley L, Al Jajeh I. Serum IgG2 and tissue IgG2 plasma cell elevation in orbital IgG4-related disease (IgG4-RD): Potential use in IgG4-RD assessment. Br J Ophthalmol. 2017;0:1-7.

Pinder SE, Campbell AF, Bartlett JM, Marshall A, Allen D, Falzon M, Dunn JA, Makris A, Hughes-Davies L, Stein RC. Discrepancies in central review re-testing of patients with ER-positive and HER2-negative breast cancer in the OPTIMA prelim randomised clinical trial. BJC. 2017; Epub.

Pollara G, Murray MJ, Heather JM, Byng-Maddick R, Guppy N, Ellis M, Turner CT, Chain BM, Noursadeghi M. Validation of Immune Cell Modules in Multicellular Transcriptomic Data. PLoS One, 2017;12(1).


Ming Lee S, Falzon M, Blackhall F, Spicer J, Nicolson M, Chaudhuri A, Middleton G, Ahmed S, Hicks J, Crosse B, Napier M, Singer JM, Ferry D, Lewanski C, Forster M, Rolls SA, Capitanio A, Rudd R, Iles N, Ngai Y, Gandy M, Lillywhite R, Hackshaw A. Randomized Prospective Biomarker Trial of ERCC1 for Comparing Platinum and Nonplatinum Therapy in Advanced Non-Small-Cell Lung Cancer: ERCC1 Trial (ET). J Clin Oncol, 2016; Epub.

Ibrahim M, Parry S, Wilkinson D, Bilbe N, Allen D, Forrest S, Maxwell P, O'Grady A, Starczynski J, Tanier P, Gosney J, Kerr K, Miller K, Thunnissen E. ALK Immunohistochemistry in NSCLC: Discordant Staining Can Impact Patient Treatment Regimen. J Clin Oncol, 2016;11(12): 2241-2247.

Scheipl S, Barnard M, Cottone L, Jorgensen M, Drewry DH, Zuercher WJ, Turlais F, Ye H, Leite AP, Smith JA, Leithner A, Moller P, Bruderlein S, Guppy N, Amary F, Tirabosco R, Strauss SJ, Pillay N, Flanagan AM. EGFR inhibitors identified as a potential treatment for chordoma in a focused compound screen. J Pathol. 2016; 239(3): 320-34.

Viale G, Paterson J, Bloch M, Csathy G, Allen D, Dell Orto P, Kjaersgaard G, Levy YY, Jorgensen JT. Analysis of HER2 status in gastroesophageal tumor specimens using a new automated HER2 IQFISH pharmDx (Dako Omnis) assay. Histol Histopathol. 2016; Epub.

Viale G, Paterson J, Bloch M, Csathy G, Allen D, Dell'Orto P, Kjaersgaard G, Levy YY, Jorgensen JT. Assessment of HER2 amplification status in breast cancer using a new automated HER2 IQFISH pharmDx (Dako Omnis) assay. Pathol Res Pract. 2016; Epub.


Hicks D, Dell Orto P, Falzon M, Hoff KD, Levy YY, McMahon L, Miller K, Russo L, Viale G. Immunohistochemical Performance of Estrogen and Progesterone Receptor Antibodies on the Dako Omnis Staining Platform: Evaluation in Multicenter Studies. Appl Immunohistochem Mol Morphol. 2015; Epub.

Salinas-Souza C, De Andrea C, Bihl M, Kovac M, Pillay N, Forshew T, Gutteridge A, Ye H, Fernanda AM, Tirabosco R, Caminada Toledo SR, Baumhoer D, Flanagan AM. GNAS mutations are not detected in parosteal and low-grade central osteosarcomas. Mod Pathol. 2015, 28; 1336-42.

Kapp JR, Diss T, Spicer J, Gandy M, Schrijver I, Jennings LJ, Li MM, Tsongalis GJ, Gonzalez de Castro D, Bridge JA, Wallace A, Deignan JL, Hing S, Butler R, Verghese E, Latham GJ, Hamoudi RA. Variation in pre-PCR processing of FFPE samples leads to discrepancies in BRAF and EGFR mutation detection: a diagnostic RING trial. J Clin Pathol. 2015, 68; 111-18.


Howat WJ, Lewis A, Jones P, Kampf C, Ponten F, van der Loos CM, Gray N, Womack C, Warford A. Antibody validation of immunohistochemistry for biomarker discovery: Recommendations of a consortium of academic and pharmaceutical based histopathology researchers. Methods. 2014; 70: 34-38.

Smith PJ, Levine AP, Dunne J, Guilhamon P, Turmaine M, Sewell GW, PhD, O Shea NR, Vega R, Paterson JC, Oukrif D, Beck S, Bloom SL, Novelli M, Rodriguez-Justo M, Smith AM, Segal AW. Mucosal Transcriptomics Implicates Under Expression of BRINP3 in the Pathogenesis of Ulcerative Colitis. Inflamm Bowel Dis. 2014; 20: 1802-12.

Allen D, Gandy M, Mackie S, Starszynski J, Saetta A, Ellery P, Archard N, Falzon M. ALK testing in NSCLC: The clinical experience and perspective of a large UK Tertiary Referral Centre. Oral Presentation at 26th European Congress of Pathology. 2014.


Behjati S, Tarpey PS, Presneau N, Scheipl S, Pillay N, Van Loo P, Wedge DC, Cooke SL, Gundem G, Davies H, Nik-Zainal S, Martin S, McLaren S, Goody V, Robinson B, Butler A, Teague JW, Halai D, Khatri B, Myklebost O, Baumhoer D, Jundt G, Hamoudi R, Tirabosco R, Amary MF, Futreal PA, Stratton MR, Campbell PJ, Flanagan AM. Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone. Nat Genetics. 2013, 45; 1479-82.


Starczynski J, Atkey N, Connelly Y, O'Grady A, Campbell FM, di Palma S, Wencyk P, Jasani B, Gandy M, Bartlett, JMS. HER2 Gene Amplification in Breast Cancer, A Rogues' Gallery of Challenging Diagnostic Cases: UKNEQAS Interpretation Guidelines and Research Recommendations. Am.J.Clin.Pathol. 2012; 137: 595-605.


Bartlett JMS, Starczynski J, Atkey N, Kay E, O'Grady A, Gandy M, Ibrahim M, Jasani B, Ellis IO, Pinder SE, Walker RA. HER2 testing in the UK: Recommendations for Breast and Gastric in-situ hybridisation Methods. J.Clin.Pathol. 2011; 64: 649-653.

du Parcq P, Munson PJ, Nelson J, Miller KD, Diss TC, Gandy M. EGFR Mutations in Non-Small Cell Lung Cancer: An update of 2 years laboratory testing. Poster Presentation at Institute of Biomedical Science Annual Congress. 2011.

Quinn J, Glassford J, Percy L, Munson PJ, Marafioti T, Rodgriguez-Justo M, Yong K. APRIL promotes cell cycle progression in primary multiple myeloma cells: influence of D-type cyclin group and translocation status. BLOOD. 2011; Jan 20;117(3): 890-901.

Blanc V, Nariculam J, Munson PJ, Freeman A, Klocker H, Masters JRW, Williamson M.  A role for Class 3 semaphorins in prostate cancer. Prostate. 2011; May; 71(6):649-58.

Ibrahim M, Bartlett JMS, Miller KD, Jasani B. Breast Cancer Biomarkers: Prognostic and Predictive Value and External Quality Assurance. Chapter 24 in Breast Pathology: Foundations in Diagnostic Pathology - Expert Consult. Edited by O'Malley FP, Pinder, SE, Mulligan, AM & Goldblum JR (Series Editor). 2011. 2nd Edition.

Bartlett JMS, Campbell FM, Ibrahim M, O'Grady A, Kay E, Faulkes C, Collins N, Starczynski J, Morgan JM, Jasani J, Miller KD. A UKNEQAS ISH Multicenter Ring Study Using the Ventana HER2 Dual-Color ISH Assay. Am.J Clin.Pathol. 2011; 135: 157-162.


Hammond ME, Hayes DF, Allred DC, Dowsett M, Hagerty KL, Badve S, Fitzgibbons PL, Francis G, Goldstein NS, Hayes M,. Hicks DG, Lester S, Love R, Mangu PB, McShane L, Miller KD, Osborne CK, Paik S, Perlmutter J, Rhodes A, Sasano H, Schwartz JN, Sweep FC, Taube S, Torlakovic EE, Valenstein P, Viale G, Visscher D, Wheeler T, Williams RB, Wittliff JL, Wolff AC. American Society of Clinical Oncology/College of American Pathologists Guideline Recommendations for Immunohistochemical Testing of Estrogen and Progesterone Receptors in Breast Cancer. J.Clin.Oncol. 2010; 28(21): 3543.

Wang Q, Symes AJ, Kane CA, Freeman A, Nariculam J, Munson PJ, Thrasivoulou C, Masters JRW, Ahmed A. A novel role for Wnt/CA2+ signaling in actin cytoskeleton remodelling and cell motility in prostate cancer. Plos One 5, e10456. 2010

Bartlett JMS, Campbell FM, Ibrahim M, Thomas J, Wencyk P, Ellis I, Kay E, Connolly Y, O'Grady A, Barnett S, Starczynski J, Cunningham P, Miller KD. A UK NEQAS ICC and ISH multicentre study using the Kreatech Poseidon HER2 FISH probe: intersite variation can be rigorously controlled using FISH. Histopathology. 2010 Feb; 56(3): 297-304.


Rodriguez-Justo M, Attygalle AD, Munson PJ, Roncador G, Marafioti T, Piris MA.  Angioimmunoblastic T-cell lymphoma with hyperplastic germinal centres: a neoplasia with origin in the outer zone of the germinal centre? Clinopathological and immunohistochemical study of 10 cases with follicular T-cell markers. Mod.Pathol. 2009; Jun; 22(6): 753-61.

Bartlett JMS, M. Campbell FM, Ibrahim M, Wencyk P, Ellis I, Kay E, Connolly Y, O'Grady A, Di Palma S, Starczynski J, Morgan JM, Jasani B, Miller KD. Chromogenic In Situ Hybridization: A Multicenter Study Comparing Silver in Situ Hybridization with FISH. Am. J.Clin Pathol. 2009; 132: 514-520.

Bartlett JMS, Ibrahim M, Jasani B, Morgan M, Ellis I, Kay E, Connolly Y, Campbell F, O'Grady A, Barnett S, Miller KD. External Quality Assurance of HER2 FISH and ISH Testing: Three Years of the UK National External Quality Assurance Scheme. Am.J.Clin.Pathol. 2009; 131: 106-111.


Rocha RM, Nunes C, Rocha G, Oliveira F, Sanches F, Gobbi H. Rabbit monoclonal antibodies show higher sensitivity than mouse monoclonals for estrogen and progesterone receptor evaluation in breast cancer by immunohistochemistry. Pathology - Research and Practice 204. 2008; 655-662.

Nunes CB, Rocha RM, Reis-Filho JS, Lambros M, Rocha GFS, Sanches FSF, Oliveira FN, Gobbi H. Comparative analysis of six different antibodies against Her2 including the novel rabbit monoclonal antibody (SP3) and chromogenic in situ hybridisation in breast carcinomas. J.Clin.Pathol. 2008; 61:934-938.

Bacon C, Paterson J, Liu H, Payne K, Munson PJ, Du M-Q, Marafioti T. Peripheral T cell lymphoma with a follicular growth pattern: derivation from follicular Helper T (TFH) cells and relationship to angioimmunoblastic T cell lymphoma. Histopathology (in press) 2008.

Gobbi H, Rocha RM, Nunes CB. Predictive factors of breast cancer evaluated by immunohistochemistry. J.Bras.Patol.Med.Lab. April 2008;44(2):131-140.

Rodriguez-Justo M, Huang Y, Ye H, Lui H, Munson PJ, Chuang S, Kim I, Du M, Bacon C. Cyclin D1-positive Diffuse Large B Cell Lymphoma. Histopathology. 2008; 52: 889-904.


Wong OG, Nitkunan T, Oinuma I, Zhou C, Blanc V, Brown RS, Bott SR, Nariculam J, Box G, Munson PJ, Constantinou J, Feneley MR, Klocker H, Eccles SA, Negishi M, Freeman A, Masters JR, Williamson M. Plexin-B1 mutations in prostate cancer. Proc.Natl.Acad.Sci.USA. 2007 nov 27; 104(48): 19040-5.

Deheragoda MG, Church NI, Rodriguez-Justo M, Munson PJ, Sandanayake N, Seward EW, Miller KD, Novelli M, Pereira SP, Hatfield ARW, Webster GJM. The utility of IgG4 immunostaining in the diagnosis of pancreatic and extra-pancreatic involvement in autoimmune pancreatitis. Clin Gastroenterol & Hepatol: 2007 Oct; 5(10): 1229-34.

Munson PJ. Immunohistochemistry. In: Patel HRH, Arya M, Shergill I (eds) (2007). Basic Science Techniques in Clinical Practice, London, Springer, pp 18-30.

Zhou Y, Attygalle AD, Chuang SS, Diss T, Ye H, Liu H, Hamoudi RA, Munson PJ, Bacon CM, Dogan A, Du MQ. Angioimmunoblastic T cell lymphoma: histological progression associates with EBV and HHV6B viral load. Br.J.Haematol. 2007 Jul; 138(1): 44-53.

Bartlett JM, Ibrahim M, Jasani B, Morgan JM, Ellis I, Kay E, Magee H, Barnett S, Miller KD. External quality assurance of HER2 fluorescence in situ hybridisation testing: results of a UK NEQAS pilot scheme. J.Clin.Pathol. 2007 Jul; 60(7): 816-9.

Miller KD, Ibrahim M, Barnett S, Jasani B. Technical aspects of predictive and prognostic markers in breast cancer: What UKNEQAS Data show. Current.Diag.Pathol. 2007, 13, 135-149.


Obermann E, Eward KL, Dogan A, Paul E, Loddo M, Munson PJ, Williams G, Stoeber K. DNA replication licensing in peripheral B-cell lymphoma. J.Pathol. 2005 Feb: 205(3): 318-28.


Freeman A, Geddes N, Munson PJ, Joseph J, Ramani P, Sandison A, Fisher C, Parkinson MC. Anaplastic lymphoma kinase (ALK-1) staining and molecular analysis in inflammatory myofibroblastic tumours of the bladder: a preliminary clinicopathological study of nine cases and review of the literature. Mod.Pathol. 2004 Jul; 17(7): 765-71.

Birtle AJ, Freeman A, Munson PJ. The androgen receptor revisited in urothelial carcinoma. Histopathology. 2004 Jul; 45(1): 98-99.

Ellis IO, Bartlett J, Dowsett M, Humphreys S, Jasani B, Miller KD, Pinder SE, Rhodes A, Walker R. Best Practice No 176: Updated recommendations for HER2 testing in the UK. J.Clin.Pathol. 2004 Mar; 57(3): 233-7

Obermann EC, Diss TC, Hamoudi RA, Munson PJ, Wilkins BS, Camozzi ML, Isaacson PG, Du MQ, Dogan A. Loss of heterozygosity at chromosome 9p21 is a frequent finding in enteropathy-type T-cell lymphoma. J.Pathol. 2004 Feb; 202(2): 252-62.

Attygalle AD, Diss TC, Munson PJ, Isaacson PG, Du MQ, Dogan A. CD10 expression in extranodal dissemination of angioimmunoblastic T-cell lymphoma. Am.J.Surg.Pathol. 2004 Jan; 28(1): 54-61.


Morner A, Thomas JA, Bjorling E, Munson PJ, Lucas SB, McKnight A. Productive HIV-2 infection in the brain is restricted to macrophages/microglia. AIDS. 2003 Jul; 17(10): 1451-55.


Freeman A, Treurnicht K, Munson PJ, Miller KD, Parkinson MC. A comparison of basal cell markers used in the prostate. Histopathology. 2002 May; 40(5): 492-94.

Attygalle A, Al-Jehani R, Diss TC, Munson PJ, Liu H, Du MQ, Issacson PG, Dogan A. Neoplastic T cells in angioimmunoblastic T-cell lymphoma express CD10. Blood. 2002 Jan 15; 99(2): 627-33.


Dogan A, Bagdi E, Munson PJ, Isaacson PG. CD10 and bcl-6 expression in paraffin sections of normal lymphoid tissue and B-cell lymphomas. Am J Surg.Pathol. 2000 Jun; 24(6): 846-52.

Pezzella F, Munson PJ, Miller KD, Goldstone AH, Gatter KC. The diagnosis of low-grade peripheral B-cell neoplasms in bone marrow trephines. Br J Haematology. 2000 Feb; 108(2): 369-76.


Brimmell M, Burns JS, Munson PJ, McDonald L, O'Hare MJ, Lakhani SR, Packham G. High level expression of differentially localized BAG-1 isoforms in some oestrogen receptor-positive human breast cancers. Br.J.Cancer. 1999 Nov; 81(6): 1042-51.

Bagdi E, Diss TC, Munson PJ, Isaacson PG. Mucosal intra-epithelial lymphocytes in enteropathy-associated T-cell lymphoma, ulcerative jejunitis and refractory celiac disease constitute a neoplastic population. Blood. 1999 Jul; 94(1): 260-64.

Chan JK, Miller KD, Munson PJ, Isaacson PG. Immunostaining for cyclin D1 and the diagnosis of mantle cell lymphoma: is there a reliable method? Histopathology. 1999 Mar; 34(3): 266-70.